Prognostic performance of early absence of pupillary light reaction after recovery of out of hospital cardiac arrest. (June 2018)

• Record Type: Journal Article
• Authors: Javaudin, F.; Leclere, B.; Segard, J.; Le Bastard, Q.; Pes, P.; Penverne, Y.; Le Conte, P.; Jenvrin, J.; Hubert, H.; Escutnaire, J.; Batard, E.; Montassier, E.; GR-RéAC,
• Is Part Of: Resuscitation. Volume 127(2018)
• Page Start: 8
• Page End: 13
• Publication Date: 2018-06
• Subjects: Pupillary light reaction -- Out of hospital cardiac arrest -- Outcome -- Prognostication; Resuscitation -- Periodicals; Resuscitation -- Periodicals; Réanimation -- Périodiques; Electronic journals; 616.025
• DOI: 10.1016/j.resuscitation.2018.03.020
• Languages: English
• ISSNs: 0300-9572

Abstract

Abstract: Introduction: Loss of pupillary light reactivity (PLR) three days after a cardiorespiratory arrest is a prognostic factor. Its predictive value upon hospital admission remains unclear. Our objective was to determine the prognostic value of the absence of PLR upon hospital admission in patients with out-of-hospital cardiac arrest. Methods: We prospectively included all out-of-hospital cardiac arrests occurring between July 2011 and July 2017 treated by a mobile medical team (MMT) based on data from a French cardiac arrest registry database. PLR was evaluated upon hospital admission and the outcome on day 30. The prognosis was classified as good for Cerebral Performance Category (CPC) 1 or 2, and poor for CPC 3–5 or in case of death. Results: Data from 10151 patients was analysed. The sensitivity and specificity of the absence of PLR for a poor outcome were 72.2% (71.2–73.2) and 68.8% (66.7–70.1), respectively. We identified several variables modifying the sensitivity values and the false positive fraction of a factor, ranging from 0.49 (0.35–0.69) for the Glasgow Coma Scale to 2.17 (1.09–2.48) for pupillary asymmetry. Among those living with CPC 1 or 2 on day 30 (n = 1990; 19.6%), 621 (31.2% (29.2–33.3)) had no PLR upon hospital admission. In the multivariate analysis, loss of PLR was associated with a poor outcome (OR = 3.1 (2.7–3.5)). Conclusions: Loss of pupillary light reactivity upon hospital admission is predictive of a poor outcome after out-of-hospital cardiac arrest. However, it does not have sufficient accuracy to determine prognosis and decision making.