Genistein supplementation improves insulin resistance and inflammatory state in non-alcoholic fatty liver patients: A randomized, controlled trial. Issue 4 (August 2018)

• Record Type: Journal Article
• Authors: Amanat, Sasan; Eftekhari, Mohammad Hassan; Fararouei, Mohammad; Bagheri Lankarani, Kamran; Massoumi, Seyed Jalil
• Is Part Of: Clinical nutrition. Volume 37:Issue 4(2018)
• Page Start: 1210
• Page End: 1215
• Publication Date: 2018-08
• Subjects: Non-alcoholic fatty liver disease -- Genistein -- Insulin resistance -- Inflammation; NAFLD non-alcoholic fatty liver disease -- MDA malondialdehyde -- TNF-α tumor necrosis factor-α -- IL-6 interleukin-6 -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- NASH non-alcoholic steatohepatitis -- HOMA-IR homeostasis model assessment for insulin resistance -- PI3K phosphatidylinositol 3-kinase -- PKC protein kinase C -- AMPK 5'-adenosine-monophosphate-activated protein kinase -- FM fat mass -- FFM to mass -- SMM skeletal muscle mass -- LDL-C low-density lipoprotein cholesterol -- HDL-C high-density lipoprotein cholesterol -- IRS-1 Insulin receptor substrate-1 -- ROS reactive oxygen species -- SUMS Shiraz the of medical sciences; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2017.05.028
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: The beneficial effect of genistein has indicated on metabolic disorders and inflammatory state. The aim of this study was to investigate the effect of genistein supplementation on non-alcoholic fatty liver disease (NAFLD) as the hepatic manifest of metabolic syndrome. Methods: In the present randomized double-blind controlled trial, patients with NAFLD were daily supplemented with either 250 mg genistein (n = 41) or placebo (n = 41) for 8-weeks. Both groups were instructed to follow an energy-balanced diet and physical activity recommendations. And their anthropometric and biochemical indices were assessed before and after the intervention. Results: At the end of the study, the genistein group had lower level of serum insulin ( p = 0.001) and homeostasis model assessment for insulin resistance (HOMA-IR) ( p = 0.041) compare to the placebo group. In addition serum malondialdehyde (MDA) ( p = 0.004), tumor necrosis factor-α (TNF-α) ( p = 0.045) and interleukin (IL)-6 ( p = 0.018) also were lower in the genistein group. Compare with placebo, genistein supplementation significantly reduced waist to hip ratio ( p = 0.021), body fat percentage ( p = 0.015) and triglyceride ( p = 0.018). However, there were no significant changes in BMI, fasting blood glucose ( p = 0.122), alanine aminotransferase (ALT) ( p = 0.536), aspartate aminotransferase (AST) ( p = 0.265) between the two groups. Conclusions: Oral supplementation with 250 mg genistein for 8-weeks can reduce insulin resistance, oxidative and inflammatory indices along with improvement in fat metabolism in patients with NAFLD. Studies with longer duration and larger samples might be needed to reveal other beneficial effects of genistein.