Clinical diagnostic and therapeutic aspects of 221 consecutive anorectal Chlamydia trachomatis and Neisseria gonorrhoeae sexually transmitted infections among men who have sex with men. (June 2018)

• Record Type: Journal Article
• Authors: Lourtet Hascoet, J.; Dahoun, M.; Cohen, M.; Pommaret, E.; Pilmis, B.; Lemarchand, N.; Mizrahi, A.; Aubert, M.; de Parades, V.; Le Monnier, A.
• Is Part Of: International journal of infectious diseases. Volume 71(2018)
• Page Start: 9
• Page End: 13
• Publication Date: 2018-06
• Subjects: Anorectal infections -- Chlamydia trachomatis -- Neisseria gonorrhoeae; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2018.03.016
• Languages: English
• ISSNs: 1201-9712

Abstract

Abstract: Objectives: Proctitis caused by Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) are known as sexually transmitted infections (STI). This study describes their clinical, diagnostic and therapeutic aspects. Methods: Between 01/2013-03/2015, all MSM consulting for proctitis at proctology Institute-Saint-Joseph's Hospital, Paris, were included. Demographic, past-medical history, STI status and medical treatment were collected. Detection of CT/NG was performed by Transcription-Mediated Amplification ( TMA ) and antimicrobial susceptibilities for Ng by agar diffusion method. Results: On 441 rectal samples collected, 221 (50.1%) were positive: 109 Ct (49.3%), 70 Ng (31.7%), 42 positive for both etiologies (19%). Among Ng infections, no resistance was detected to azithromycin and ceftriaxone. However, 84 strains (43.2%) were resistant to fluoroquinolones. More than one episode was diagnosed for 10 (5.1%) and 12 (6.2%) patients with CT and NG infections respectively. Anal abscesses were found for 27 (13.9%) patients, and 14 (7.2%) of them underwent surgery for anal fistula. Conclusions: The prevalence of CT/NG anorectal infections described is high on symptomatic patients, and a significant level of abscess was reported. These results confirm the interest of the association of recommended antibiotics excluding quinolones. Prospective studies would be relevant on complicated forms of anorectal infections.