Microglial modulation of neuronal activity in the healthy brain. Issue 6 (26th December 2017)

• Record Type: Journal Article
• Authors: York, Elisa M.; Bernier, Louis‐Philippe; MacVicar, Brian A.
• Other Names: Stevens Beth guestEditor.; Schafer Dorothy P. guestEditor.
• Is Part Of: Developmental neurobiology. Volume 78:Issue 6(2018)
• Page Start: 593
• Page End: 603
• Publication Date: 2017-12-26
• Subjects: microglia -- synapse homeostasis -- synaptic plasticity; Neurobiology -- Periodicals; Neurobiology; Neurobiologie -- Périodiques; Neurobiology; Periodicals; Periodicals; 573.838
• DOI: 10.1002/dneu.22571
• Languages: English
• ISSNs: 1932-8451

Abstract

ABSTRACT: Investigations on the role of microglia in the brain have traditionally been focused on their contributions to disease states. However, recent observations have now convincingly shown that microglia in the healthy brain are not passive bystanders, but instead play a critical role in both central nervous system development and homeostasis of synaptic circuits in the adult. Here, we review the various mechanisms by which microglia impact neuronal communication in the healthy adult brain, both by sensing nearby synaptic responses and by actively modulating neuronal function. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 593–603, 2018