Intraindividual Pharmacokinetic Variability: Focus on Small‐Molecule Kinase Inhibitors. Issue 6 (1st December 2017)

• Record Type: Journal Article
• Authors: Chatelut, Etienne; Bruno, René; Ratain, Mark J.
• Is Part Of: Clinical pharmacology & therapeutics. Volume 103:Issue 6(2018)
• Page Start: 956
• Page End: 958
• Publication Date: 2017-12-01
• Subjects: Pharmacology -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1002/cpt.937
• Languages: English
• ISSNs: 0009-9236

Abstract

Abstract : The magnitude of interindividual pharmacokinetic variability (IIV) of a drug and the factors responsible for this variability are intensively studied before—and sometimes after—registration as crucial information in anticipating and understanding variability in toxicity and efficacy. However, there has been much less attention paid to intraindividual variability, reflecting random or systematic changes in an individual's pharmacokinetics over time. We have chosen to focus on small‐molecule kinase inhibitors (SMKIs).