Optimal detection of infratentorial lesions with a combined dual-echo MRI sequence: "PT2". (September 2016)

• Record Type: Journal Article
• Authors: Gaitán, María I; Yañes, Paulina; Sati, Pascal; Romero, Carlos; Reich, Daniel S; Correale, Jorge
• Is Part Of: Multiple sclerosis. Volume 22:Number 10(2016)
• Page Start: 1367
• Page End: 1370
• Publication Date: 2016-09
• Subjects: Multiple sclerosis -- MRI -- infratentorial brain -- T2 lesions; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458515615226
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The infratentorial compartment is cardinal for multiple sclerosis (MS) diagnosis. T2-weighted (T2) and proton density–weighted (PD) magnetic resonance imaging (MRI) can visualize infratentorial lesions, but only suboptimally. Objective: To combine PD and T2 for better lesion assessment. Methods: T2 and PD from 35 cases were averaged to form "PT2" images. Two raters counted infratentorial lesions and qualitatively assessed their conspicuity. Results: PT2 showed 244 infratentorial lesions, of which 94% and 74% were seen in PD and T2. PT2 received higher grades for image quality and lesion conspicuity ( p < 0.001 for all comparisons). Conclusion: PT2 could improve our ability to diagnose and monitor MS.