Multiphasic disseminated encephalomyelitis followed by optic neuritis in a child with gluten sensitivity. (August 2015)

• Record Type: Journal Article
• Authors: Ching, BH; Mohamed, AR; Khoo, TB; Ismail, HIHM
• Is Part Of: Multiple sclerosis. Volume 21:Number 9(2015)
• Page Start: 1209
• Page End: 1211
• Publication Date: 2015-08
• Subjects: Multiphasic disseminated encephalomyelitis -- optic neuritis -- gluten sensitivity; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458515593404
• Languages: English
• ISSNs: 1352-4585

Abstract

Multiphasic disseminated encephalomyelitis (MDEM) followed by optic neuritis (ON) has been described as a new entity in recent years. Gluten encephalopathy has also been recognized as a neurological manifestation of celiac disease. Accurate diagnosis of both is important due to the therapeutic implications. We report a girl presenting with recurrent encephalopathic polyfocal demyelinating episodes followed by optic neuritis, and a clinical history suggestive of gluten sensitivity. She had persistently high ESR, neutrophilia, and tested positive for anti-MOG (myelin oligodendrocyte glycoprotein) antibody. She responded well to methylprednisolone in each relapse, and achieved remission for a year after azathioprine was added.