Brain death organ donor supported by a left ventricular assist device showing unexpected congestive liver fibrosis: A case report. (2018)

• Record Type: Journal Article
• Authors: Kamei, Hideya; Komagome, Masahiko; Kurata, Nobuhiko; Ogiso, Satoshi; Onishi, Yasuharu; Hara, Takanobu; Takatsuki, Mitsuhisa; Eguchi, Susumu; Ogura, Yasuhiro
• Is Part Of: International journal of surgery case reports. Volume 47(2018)
• Page Start: 57
• Page End: 60
• Publication Date: 2018
• Subjects: ALT alanine transaminase -- AST aspartate transaminase -- CT computed tomography -- LT liver transplantation -- LVAD left ventricular assist device; Liver transplantation -- Extended criteria donor -- Mechanical circulatory support system -- Cardiac hepaotopathy; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2018.04.026
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: We report a case in which a brain death donor, supported by a left ventricular assist device, with significant congestive fibrosis of the liver. This case serves as a note of caution when addressing organ procurement from brain death donor with left ventricular assist device. Exposure of the surgical fields was restricted by the device and drive lines. It also should be noted that chronic heart failure can lead to subclinical advanced liver fibrosis. Abstract: Instruction: Organ transplantation from a brain death donor on mechanical circulatory support is rare. We report a case in which a brain death donor, supported by a left ventricular assist device (LVAD), unexpectedly displayed significant congestive fibrosis of the liver. Presentation of case: The potential organ donor was diagnosed 23 years previously as having dilated-phase of hypertrophic cardiomyopathy. He had undergone implantation of an LVAD as a bridge to heart transplantation. Laboratory tests and imaging studies performed during the follow-up for his cardiac disease and donor evaluation confirmed that he was suitable for donation of liver. During organ procurement, special attention was paid to preserving LVAD and its device's drive lines and the exposure of the surgical fields was restricted by those devices. Thoracotomy and laparotomy were performed, and the aorta and inferior vena cava were encircled successfully. The gross appearance of liver, however, suggested significant fibrosis. Therefore, the decision was made not to use this liver. Subsequent trichrome-stained permanent sections revealed advanced fibrosis (stage F3–4). Discussion: As previously reported, organ procurement from donors with LVAD was thought to be demanding procedure because of the limited exposure of surgical field. In addition, it would be difficult to predict severe liver fibrosis in patients with an LVAD without a pathological examination. Conclusion: Donors with mechanical circulatory support systems can be candidate to expand the donor pool, but technical difficulty should be expected owing limited exposure during the donor operation. For liver transplantation, subclinical advanced liver fibrosis should be noted.