Inverse correlation of genetic risk score with age at onset in bout-onset and progressive-onset multiple sclerosis. (October 2015)

• Record Type: Journal Article
• Authors: Sorosina, Melissa; Esposito, Federica; Guaschino, Clara; Clarelli, Ferdinando; Barizzone, Nadia; Osiceanu, Ana Maria; Brambilla, Paola; Mascia, Elisabetta; Cavalla, Paola; Gallo, Paolo; Martinelli, Vittorio; Leone, Maurizio; Comi, Giancarlo; D'Alfonso, Sandra; Martinelli Boneschi, Filippo
• Is Part Of: Multiple sclerosis. Volume 21:Number 11(2015)
• Page Start: 1463
• Page End: 1467
• Publication Date: 2015-10
• Subjects: Primary-progressive -- relapsing–remitting -- multiple sclerosis -- age of onset -- weighted genetic risk score -- genetic risk; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458514561910
• Languages: English
• ISSNs: 1352-4585

Abstract

We correlated the weighted genetic risk score measured using 107 established susceptibility variants for multiple sclerosis (MS) with the age at onset in bout-onset (BOMS, n =906) and progressive-onset MS Italian patients (PrMS) ( n =544). We observed an opposite relationship in the two disease courses: a higher weighted genetic risk score was associated with an earlier age at onset in BOMS (rho= −0.1; p =5 × 10 −3 ) and a later age at onset in PrMS cases (rho=0.07; p =0.15) ( p of difference of regression=1.4 × 10 −2 ). These findings suggest that established MS risk variants anticipate the onset of the inflammatory phase, while they have no impact on, or even delay, the onset of the progressive phase.