Using 2H labelling to improve the NMR detectability of pyridine and its derivatives by SABRE. (25th January 2018)

• Record Type: Journal Article
• Authors: Norcott, Philip; Burns, Michael J.; Rayner, Peter J.; Mewis, Ryan E.; Duckett, Simon B.
• Other Names: Dumez Jean‐Nicolas guestEditor.
• Is Part Of: Magnetic resonance in chemistry. Volume 56:Number 7(2018)
• Page Start: 663
• Page End: 671
• Publication Date: 2018-01-25
• Subjects: hyperpolarisation -- NMR -- parahydrogen -- SABRE; Nuclear magnetic resonance spectroscopy -- Periodicals; Chemistry, Organic -- Periodicals; Magnetic resonance -- Periodicals; 538.36
• DOI: 10.1002/mrc.4703
• Languages: English
• ISSNs: 0749-1581

Abstract

Abstract : By introducing a range of 2 H labels into pyridine and the para ‐substituted agents, methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T 1 relaxation for the remaining 1 H nuclei are increased and show how this leads to a concomitant increase in the level of 1 H and 13 C hyperpolarization that can ultimately be detected. Abstract : By introducing a range of 2 H labels into pyridine and the para ‐substituted agents methyl isonicotinate and isonicotinamide, we significantly improve their NMR detectability in conjunction with the signal amplification by reversible exchange process. We describe how the rates of T 1 relaxation for the remaining 1 H nuclei are increased and show how this leads to a concomitant increase in the level of 1 H and 13 C hyperpolarization that can ultimately be detected.