Association Between Perinatal Hypoxic-Ischemic Conditions and Attention-Deficit/Hyperactivity Disorder: A Meta-Analysis. (September 2016)

• Record Type: Journal Article
• Authors: Zhu, Tingting; Gan, Jing; Huang, Jichong; Li, Yafei; Qu, Yi; Mu, Dezhi
• Is Part Of: Journal of child neurology. Volume 31:Number 10(2016:Oct.)
• Page Start: 1235
• Page End: 1244
• Publication Date: 2016-09
• Subjects: hypoxia -- ischemia -- risk factor -- ADHD -- meta-analysis; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073816650039
• Languages: English
• ISSNs: 0883-0738

Abstract

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neuropsychiatric disorder worldwide, but its etiology is still not fully understood. Previous studies have reported that perinatal hypoxic-ischemic conditions may be a potential cause of ADHD. Methods: An online search of potential English studies published before September 2015 was conducted using the PsycINFO, EMBASE, Web of Science, and PubMed databases. The combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated with random-effects models. Results: Ten studies were included, with 45 821 cases and 9 207 363 controls. The metaresults found that the following were associated with ADHD: preeclampsia (OR 1.31; 95% CI 1.26-1.37), an Apgar score <7 at 5 minutes (OR 1.31; 95% CI 1.12-1.54), breech/transverse presentations (OR 1.14; 95% CI 1.06-1.23), and a prolapsed/nuchal cord (OR 1.10; 95% CI 1.06-1.15). Conclusion: Our results support that perinatal hypoxia-ischemia may contribute to ADHD. However, more clinical studies are warranted.