Burden of HIV-Related Neuropathic Pain in the United States. (March 2016)

• Record Type: Journal Article
• Authors: Mann, Rachael; Sadosky, Alesia; Schaefer, Caroline; Baik, Rebecca; Parsons, Bruce; Nieshoff, Edward; Stacey, Brett R.; Tuchman, Michael; Nalamachu, Srinivas
• Is Part Of: Journal of the International Association of Providers of AIDS Care. Volume 15:Number 2(2016:Mar./Apr.)
• Page Start: 114
• Page End: 125
• Publication Date: 2016-03
• Subjects: HIV -- neuropathic pain -- burden of illness -- quality of life -- health care resource use -- costs -- productivity -- pain assessment; AIDS (Disease) -- Periodicals; 616.9792
• DOI: 10.1177/2325957415592474
• Languages: English
• ISSNs: 2325-9574

Abstract

Background: HIV-related neuropathic pain (HIV-NeP) is common; however, the burden of HIV-NeP is not well-understood. Methods: The cross-sectional study aimed to characterize the HIV-NeP burden. A total of 103 patients with HIV-NeP recruited during routine office visits completed a questionnaire to assess patient-reported outcomes, including pain severity, health status, sleep, mood, and lost productivity. Physicians completed a 6-month retrospective chart review. Results: The sample was predominantly male and not employed for pay. A majority (75.7%) of patients experienced moderate or severe pain. Pain interference, general health, physical health, and depression were worse among patients with more severe pain (all P s < .006). Most (87.4%) patients were prescribed at least 1 medication for NeP. HIV-related neuropathic pain was associated with 36.1% work impairment. Adjusted annualized costs increased with increasing pain severity ( P < .0001). Conclusion: The impact of HIV-NeP on health status, physical function, and depression increases with severity, resulting in substantial clinical and economic burden.