Reliability of pulse waveform separation analysis: effects of posture and fasting. Issue 3 (March 2017)

• Record Type: Journal Article
• Authors: Stoner, Lee; Credeur, Daniel; Fryer, Simon; Faulkner, James; Lambrick, Danielle; Gibbs, Bethany Barone
• Is Part Of: Journal of hypertension. Volume 35:Issue 3(2017:Mar.)
• Publication Date: 2017-03
• Subjects: arterial wave reflection -- augmentation index -- central blood pressure -- fasting -- oscillometry -- postprandial -- posture -- pulse wave analysis -- reproducibility; Hypertension -- Periodicals; Hypertension -- Periodicals; 616.132005
• DOI: 10.1097/HJH.0000000000001182
• Languages: English
• ISSNs: 1473-5598

Abstract

Abstract : Objective: Oscillometric pulse wave analysis devices enable, with relative simplicity and objectivity, the measurement of central hemodynamic parameters. The important parameters are central blood pressures and indices of arterial wave reflection, including wave separation analysis (backward pressure component P b and reflection magnitude). This study sought to determine whether the measurement precision (between-day reliability) of P b and reflection magnitude: exceeds the criterion for acceptable reliability; and is affected by posture (supine, seated) and fasting state. Methods: Twenty healthy adults (50% female, 27.9 years, 24.2 kg/m 2 ) were tested on six different mornings: 3 days fasted, 3 days nonfasted condition. On each occasion, participants were tested in supine and seated postures. Oscillometric pressure waveforms were recorded on the left upper arm. Results: The criterion intra-class correlation coefficient value of 0.75 was exceeded for P b (0.76) and reflection magnitude (0.77) when participants were assessed under the combined supine-fasted condition. The intra-class correlation coefficient was lowest for P b in seated-nonfasted condition (0.57), and lowest for reflection magnitude in the seated-fasted condition (0.56). For P b, the smallest detectible change that must be exceeded in order for a significant change to occur in an individual was 2.5 mmHg, and for reflection magnitude, the smallest detectable change was 8.5%. Conclusion: Assessments of P b and reflection magnitude are as follows: exceed the criterion for acceptable reliability; and are most reliable when participants are fasted in a supine position. The demonstrated reliability suggests sufficient precision to detect clinically meaningful changes in reflection magnitude and P b .