An individual-based model for biofilm formation at liquid surfaces. (8th December 2015)

• Record Type: Journal Article
• Authors: Ardré, Maxime; Henry, Hervé; Douarche, Carine; Plapp, Mathis
• Is Part Of: Physical biology. Volume 12:Number 6(2015:Dec.)
• Publication Date: 2015-12-08
• Subjects: biofilms -- modelling -- bacillus subtilis -- pattern formation; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biology -- Data processing -- Periodicals; 570.5
• DOI: 10.1088/1478-3975/12/6/066015
• Languages: English
• ISSNs: 1478-3967

Abstract

Abstract: The bacterium Bacillus subtilis frequently forms biofilms at the interface between the culture medium and the air. We present a mathematical model that couples a description of bacteria as individual discrete objects to the standard advection-diffusion equations for the environment. The model takes into account two different bacterial phenotypes. In the motile state, bacteria swim and perform a run-and-tumble motion that is biased toward regions of high oxygen concentration (aerotaxis). In the matrix-producer state they excrete extracellular polymers, which allows them to connect to other bacteria and to form a biofilm. Bacteria are also advected by the fluid, and can trigger bioconvection. Numerical simulations of the model reproduce all the stages of biofilm formation observed in laboratory experiments. Finally, we study the influence of various model parameters on the dynamics and morphology of biofilms.