Four new diterpenoid alkaloids with anti-inflammatory activities from Aconitum taronense Fletcher et Lauener. (June 2018)

• Record Type: Journal Article
• Authors: Yin, Tianpeng; Hu, Xiaofang; Mei, Ruifeng; Shu, Yan; Gan, Dong; Cai, Le; Ding, Zhongtao
• Is Part Of: Phytochemistry letters. Volume 25(2018)
• Page Start: 152
• Page End: 155
• Publication Date: 2018-06
• Subjects: Aconitum taronense -- Ranunculaceae -- Diterpenoid alkaloid -- Taronenine -- Anti-inflammatory -- Interleukin-6; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2018.04.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Four new C19 -diterpenoid alkaloids were isolated from Aconitum taronense . New alkaloids 1, 2 and 4 showed certain inhibition activities of IL-6 in LPS-activated RAW 264.7 cells. Aconitum taronense was phytochemically investigated for the first time. Abstract: Four new C19 -diterpenoid alkaloids, named taronenines A-D (1 -4 ), have been isolated from the roots of Aconitum taronense Fletcher et Lauener (Ranunculaceae), which has long been used as a folk medicine to treat rheumatism and arthritis in China. Their structures were established on the basis of extensive spectroscopic analyses. The isolated compounds were evaluated for their potential anti-inflammatory effects using LPS-stimulated RAW 264.7 macrophages. Compounds1, 2 and4 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 29.60 ± 0.08 μg/mL, 18.87 ± 0.14 μg/mL, and 25.39 ± 0.11 μg/mL, respectively.