Increased Expression of Matrix Metalloproteinases in Ligamentum Flavum Hypertrophy of the Patients with Lumbar Spinal Stenosis. (1st March 2016)

• Record Type: Journal Article
• Authors: Eser, Betul; Eser, Olcay; Simsek, Nejdet; Bulbul, Erdogan; Guven, Mustafa
• Is Part Of: International journal of human genetics. Volume 16:Number 1/2(2016)
• Page Start: 1
• Page End: 9
• Publication Date: 2016-03-01
• Subjects: Expression -- Ligament -- Metalloproteinase -- Polymorphism -- Stenosis; Human genetics -- Periodicals; 599.935
• DOI: 10.1080/09723757.2016.11886269
• Languages: English
• ISSNs: 0972-3757

Abstract

Abstract: This paper shows an investigation of the expressions of MMP-3, -13 and their polymorphisms in patients with lumbar spinal stenosis (LSS). Hypertrophied LF tissues and peripheral bloods were obtained from 50 patients with LSS. The expressions of MMP-3, -13 and their polymorphisms were analyzed. No relationship was found between thickness of LFs and MMP-3, -13 genotypes. LF tissues were divided to three groups as grade 1, 2 and 3. Rich elastic fibrils were observed in grade 1. Elastic fibers and elastin/collagen rates decreased in grade 2-3 and 4, and collagen fibers increased and presented a cystic degeneration. MMP-3 immunopositive cells were higher than MMP-13. A correlation between LF thicknesses and MMP-3 was detected. Both MMP-3, -13 were expressed (MMP-3 in higher quantities) in high grade hypertrophied LF. The researchers expect that this paper would provide a better understanding of the pathogenesis of LF hypertrophy and lead to therapeutic alternatives for LSS patients.