A One‐Pot Synthesis of Triazolodiazepines. Issue 21 (12th June 2015)

• Record Type: Journal Article
• Authors: Hooyberghs, Geert; Van Hove, Sofie; Jacobs, Jeroen; Van Meervelt, Luc; Van der Eycken, Erik V.
• Is Part Of: European journal of organic chemistry. Issue 21(2015)
• Page Start: 4726
• Page End: 4731
• Publication Date: 2015-06-12
• Subjects: Diazepines -- Medium‐ring compounds -- Multicomponent reactions -- Nitrogen heterocycles -- Tandem reactions; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500402
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A one‐pot sequential A 3 ‐coupling‐azidation‐cyclisation approach leading to potentially biologically active diazepine analogues has been developed. The implementation of the A 3 ‐coupling reaction ensures diversity. Attention is given to this so far rarely studied structural motif of fused heterocyclic diazepines. Abstract : A one‐pot two‐step approach to novel [1, 2, 3]triazolo[1, 5‐ a ]diazepines has been developed. A variety of triazolodiazepines with possible biological activity is presented.