Arsenical C‐Glucoside Derivatives with Promising Antitumor Activity. Issue 21 (22nd June 2015)

• Record Type: Journal Article
• Authors: D'Orazio, Giuseppe; Parisi, Gelsomina; Policano, Claudia; Mechelli, Rosella; Codacci Pisanelli, Giovanni; Pitaro, Michele; Ristori, Giovanni; Salvetti, Marco; Nicotra, Francesco; La Ferla, Barbara
• Is Part Of: European journal of organic chemistry. Issue 21(2015)
• Page Start: 4620
• Page End: 4623
• Publication Date: 2015-06-22
• Subjects: C‐Glucosides -- Arsenic -- Antiproliferation -- GLUT transporter -- Arsenic‐glyco derivatives; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500529
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: C ‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized by avoiding protection‐deprotection steps. While compound1, bearing an As V atom, did not show any significant biological activity, compound2, in which the glucose moiety is linked to the arsenic atom as dithioarsenical (As III ), showed promising antiproliferative activity on a cell line of neuroblastoma (SK‐N‐BE). Abstract : C ‐Glucoside derivatives covalently linked to the arsenic atom in different oxidation states have been synthesized. The C ‐glucoside conjugated to the phenyldithioarsolan group, showed promising antiproliferative activity on human neuroblastoma cells (SK‐N‐BE).