Synthesis and antitumor activities of sinomenine derivatives on rings A and C. Issue 3 (4th March 2018)

• Record Type: Journal Article
• Authors: Wei, Can-Jing; Xu, Fang; Shi, Meng-Jiao; Hu, Jia-Wen; Wang, Jia-Jia; Zhen, Bo; Wang, Xue; Ji, Teng-Fei; Wang, Jin-Hua; Du, Guan-Hua
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 3(2018)
• Page Start: 277
• Page End: 291
• Publication Date: 2018-03-04
• Subjects: Sinomenine -- modification -- derivatives -- esterification -- antitumor; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1386659
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A series of new sinomenine derivatives were designed, synthesized, and evaluated in tumor inhibitory activity, such as human triple negative breast cancer cell line (MDA-MB-231), glioma cell line (A172), human lung cancer cell line (A549), human colon cancer cell line (HCT-8). The modifications were carried out on rings A and C of the sinomenine by esterificating on phenolic hydroxyl with good yields. The highlight of this work was that the synthetic procedures were concise and sinomenine derivatives demonstrated promising antitumor activities. Abstract :