Hemophagocytic lymphohistiocytosis associated to Haemophilus parainfluenzae endocarditis– a case report. Issue 3 (4th May 2018)

• Record Type: Journal Article
• Authors: Costescu Strachinaru, D. I.; Chaumont, M.; Gobin, D.; Sattar, L.; Strachinaru, M.; Karakike, E.; Roman, A.; Konopnicki, D.
• Is Part Of: Acta clinica belgica. Volume 73:Issue 3(2018)
• Page Start: 220
• Page End: 223
• Publication Date: 2018-05-04
• Subjects: Hemophagocytic lymphohistiocytosis -- Haemophilus parainfluenzae -- infective endocarditis -- case report; Clinical medicine -- Periodicals; Diagnosis, Laboratory -- Periodicals; 616.005
• DOI: 10.1080/17843286.2017.1341691
• Languages: English
• ISSNs: 1784-3286

Abstract

Abstract: Background: Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that is characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. This syndrome is classified as primary (genetic) or secondary when acquired in the context of infections (usually viral), malignancies, rheumatologic and metabolic diseases. Case summary: We report a case of HLH complicating a Haemophilus parainfluenzae mitral valve endocarditis and resolving under antibiotic and surgical treatment alone. We also review other case reports of infective endocarditis associated with HLH. Conclusion: The syndrome is probably underdiagnosed. To our knowledge, this is the first report of a HLH syndrome associated with H. parainfluenzae endocarditis.