Autonomic dysfunction in a patient with X-linked adrenoleukodystrophy. (3rd August 2018)

• Record Type: Journal Article
• Authors: Zhang, Yifan; Guo, Dongmei; Tang, Yi
• Is Part Of: International journal of neuroscience. Volume 128:Number 8(2018)
• Page Start: 783
• Page End: 784
• Publication Date: 2018-08-03
• Subjects: X-linked adrenoleukodystrophy -- autonomic dysfunction -- mitochondrial defect; Nervous system -- Periodicals; 612.805
• DOI: 10.1080/00207454.2017.1405953
• Languages: English
• ISSNs: 0020-7454

Abstract

ABSTRACT: X-linked adrenoleukodystrophy is an inherited disease caused by abnormal accumulation of very long chain fatty acids. The diagnosis of X-linked adrenoleukodystrophy can be confirmed with the mutation of ABCD1 gene. The main symptom of the X-linked adrenoleukodystrophy is spastic paraparesis, and autonomic dysfunction is rare in X-linked adrenoleukodystrophy. Here, we presented an X-ALD case of a 46-year-old Asian male with severe autonomic dysfunction. Impairment of the autonomic nervous system may closely relate to mitochondrial defect.