PAMAM-modified citric acid-coated magnetic nanoparticles as pH sensitive biocompatible carrier against human breast cancer cells. (3rd August 2018)

• Record Type: Journal Article
• Authors: Nosrati, Hamed; Adibtabar, Maral; Sharafi, Ali; Danafar, Hossein; Hamidreza Kheiri, Manjili
• Is Part Of: Drug development and industrial pharmacy. Volume 44:Number 8(2018)
• Page Start: 1377
• Page End: 1384
• Publication Date: 2018-08-03
• Subjects: Citric acid -- curcumin -- drug delivery -- iron oxide -- magnetic nanoparticles -- PAMAM -- denderimer; Pharmaceutical chemistry -- Periodicals; Pharmaceutical industry -- Periodicals; Drug Industry -- Periodicals; Technology, Pharmaceutical -- Periodicals; 615.05
• DOI: 10.1080/03639045.2018.1451881
• Languages: English
• ISSNs: 0363-9045

Abstract

Abstract: Denderimer-modified magnetic nanoparticles are a promising drug delivery nanosystem which can improve the therapeutic efficacy of chemotherapy drugs and can also be beneficial as magnetic resonance (MR) images contrast agent. The present study introduces the preparation and characterization of the potential therapeutic efficiency of curcumin (CUR)-loaded denderimer-modified citric acid coated Fe3 O4 NPs. Polyamidoamine (PAMAM, generation G5 ) was used to encapsulate citric acid coated Fe3 O4 nanoparticles. The successful preparation of CUR-loaded nanocarriers were confirmed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM), and transmission electron microscopy (TEM) techniques. The loading capacity and encapsulation efficiency of CUR molecules were 12 ± 0.03% and 45.58 ± 0.41%, respectively. The anticancer effect of void CUR and CUR-loaded nanocarriers were compared to each other by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay on treated MCF-7 cell line. It can be concluded that application of nanoparticles can be more effective strategy for controlled and slow release of CUR in human breast cancer treatment. Graphical Abstract: