Hereditary and Acquired Thrombophilia in Splanchnic Vein Thrombosis: A Single-Center Experience. (September 2015)

• Record Type: Journal Article
• Authors: Mutreja, Deepti; Kotru, Mrinalini; Sazawal, Sudha; Ranjan, Ravi; Sharma, Amit; Acharya, Subrat Kumar; Saxena, Renu
• Is Part Of: Clinical and applied thrombosis/hemostasis. Volume 21:Number 6(2015)
• Page Start: 521
• Page End: 526
• Publication Date: 2015-09
• Subjects: clinical thrombophilia -- deep venous thrombosis -- hypercoagulability -- molecular diagnostics -- thrombophilia -- thrombosis; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 616.13
• DOI: 10.1177/1076029613511520
• Languages: English
• ISSNs: 1076-0296

Abstract

The purpose of this study was to characterize differences in the prevalence of hereditary and acquired thrombophilia in patients with splanchnic vein thrombosis (SVT). A total of 88 consecutive patients with SVT, including Budd Chiari Syndrome (n = 47) and portal extrahepatic portal vein obstruction (n = 41), underwent comprehensive thrombophilia testing, including testing for heritable and acquired causes. In 33 (37.5%) patients, etiology could be explained by at least 1 of the heritable etiologic factors, and 31 (35.2%) patients could be explained by at least 1 of the acquired causes studied. The combination of multiple concurrent factors was present in 9 (11.4%) patients. Among the heritable causes, the risk of SVT was found increased in the presence of thrombophilia resulting from the deficiencies of the naturally occurring anticoagulant proteins, and the acquired thrombogenic factors were significantly associated with causation of thrombosis in adult patients with SVT.