Reassessment of nanomaterials immunotoxicity. (June 2018)

• Record Type: Journal Article
• Authors: Elsabahy, Mahmoud; Wooley, Karen L.
• Is Part Of: Nano today. Volume 20(2018)
• Page Start: 10
• Page End: 12
• Publication Date: 2018-06
• Subjects: Particles -- Nanomaterials -- Biomarkers -- Cytokines -- Multiplex -- xMAP -- Adsorption -- Immunotoxicity; Nanotechnology -- Periodicals; Nanosciences -- Périodiques; 620.505
• DOI: 10.1016/j.nantod.2018.01.002
• Languages: English
• ISSNs: 1748-0132

Abstract

Graphical abstract: Biomarkers ( e.g. cytokines) that are commonly measured to assess the immunomodulatory effects of nano- or micro-particulates may be adsorbed on their surfaces and/or absorbed within internal regions, thereby, generating an inaccurately low measure of immunotoxic effect. We provide this commentary, therefore, as a cautionary recommendation that previously published data be reassessed, and future investigations consider potential artifacts and data misinterpretation carefully. Highlights: Biomarkers may be adsorbed on the surfaces and/or absorbed within internal regions of nano- or micro-particulates. Previously published data should be reassessed. Future investigations shall consider potential artifacts and data misinterpretation carefully. Abstract: Biomarkers ( e.g. cytokines) that are commonly measured to assess the immunomodulatory effects of nano- or micro-particulates may be adsorbed on their surfaces and/or absorbed within internal regions, thereby, generating an inaccurately low measure of immunotoxic effect. We provide this commentary, therefore, as a cautionary recommendation that previously published data be reassessed, and future investigations consider potential artifacts and data misinterpretation carefully.