Antibody replacement therapy in primary antibody deficiencies and iatrogenic hypogammaglobulinemia. (August 2015)

• Record Type: Journal Article
• Authors: Hoffman, Thijs W; van Kessel, Diana A; van Velzen-Blad, Heleen; Grutters, Jan C; Rijkers, Ger T
• Is Part Of: Expert review of clinical immunology. Volume 11:Number 8(2015)
• Page Start: 921
• Page End: 933
• Publication Date: 2015-08
• Subjects: antibody replacement therapy -- iatrogenic hypogammaglobulinemia -- immunodeficiency -- immunoglobulin -- primary antibody deficiency; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1586/1744666X.2015.1049599
• Languages: English
• ISSNs: 1744-666X

Abstract

Abstract : Antibody replacement therapy has been used in the treatment of primary antibody deficiencies (PADs) for several decades, and an evidence-based guideline for its treatment is currently available. By contrast, the use of antibody replacement therapy in iatrogenic hypogammaglobulinemia (IHG), a condition that is associated with immunosuppressive medication, has hardly any evidence base and no guidelines. As IHG can be equally as severe as PAD and is much more prevalent, evidence-based guidelines are urgently needed. This review will focus on the differences and similarities between PAD and IHG and the use of antibody replacement therapy in both conditions. Suggestions for the development of evidence-based guidelines and future research are given.