Quantitative Evaluation of Adult Subglottic Stenosis Using Intraoperative Long-range Optical Coherence Tomography. (October 2016)

• Record Type: Journal Article
• Authors: Sharma, Giriraj K.; Chin Loy, Anthony; Su, Erica; Jing, Joe; Chen, Zhongping; Wong, Brian J-F.; Verma, Sunil
• Is Part Of: Annals of otology, rhinology & laryngology. Volume 125:Number 10(2016:Oct.)
• Page Start: 815
• Page End: 822
• Publication Date: 2016-10
• Subjects: subglottic stenosis -- optical coherence tomography -- airway measurement -- direct laryngoscopy -- suspension microlaryngoscopy; Otolaryngology -- Periodicals; 617.51
• DOI: 10.1177/0003489416655353
• Languages: English
• ISSNs: 0003-4894

Abstract

Objectives: To determine the feasibility of long-range optical coherence tomography (LR-OCT) as a tool to intraoperatively image and measure the subglottis and trachea during suspension microlaryngoscopy before and after endoscopic treatment of subglottic stenosis (SGS). Methods: Long-range optical coherence tomography of the adult subglottis and trachea was performed during suspension microlaryngoscopy before and after endoscopic treatment for SGS. The anteroposterior and transverse diameters, cross-sectional area (CSA), distance from the vocal cords, and length of the SGS were measured using a MATLAB software. Pre-intervention and postintervention airway dimensions were compared. Three-dimensional volumetric airway reconstructions were generated using medical image processing software (MIMICS). Results: Intraoperative LR-OCT imaging was performed in 3 patients undergoing endoscopic management of SGS. Statistically significant differences in mean anteroposterior diameter ( P < .01), transverse diameter ( P < .001), and CSA ( P < .001) were noted between pre-intervention and postintervention data. Three-dimensional airway models were viewed in cross-sectional format and via virtual "fly through" bronchoscopy. Conclusions: This is the first report of intraoperative LR-OCT of the subglottic and tracheal airway before and after surgical management of SGS in humans. Long-range optical coherence tomography offers a practical means to measure the dimensions of SGS and acquire objective data on the response to endoscopic treatment of SGS.