Endocan Levels and Subclinical Atherosclerosis in Patients With Systemic Lupus Erythematosus. (September 2016)

• Record Type: Journal Article
• Authors: Icli, Abdullah; Cure, Erkan; Cure, Medine Cumhur; Uslu, Ali Ugur; Balta, Sevket; Mikhailidis, Dimitri P.; Ozturk, Cengiz; Arslan, Sevket; Sakız, Davut; Sahin, Muhammed; Kucuk, Adem
• Is Part Of: Angiology. Volume 67:Number 8(2016)
• Page Start: 749
• Page End: 755
• Publication Date: 2016-09
• Subjects: endocan -- systemic lupus erythematosus -- atherosclerosis -- inflammation; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319715616240
• Languages: English
• ISSNs: 0003-3197

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology. A major cause of morbidity and mortality in SLE is accelerated atherosclerosis. Endothelial-specific molecule 1 (endocan) is a potential predictor of vascular events and is expressed in response to inflammatory cytokines in endothelial cells. We investigated the relationship between endocan and carotid intima–media thickness (cIMT) as a marker of early atherosclerosis. We included 44 women with SLE and 44 healthy women as controls. Disease severity of SLE was evaluated using the SLE Disease Activity Index. Endocan, C-reactive protein, erythrocyte sedimentation rate (ESR), and lipid panel were measured. The cIMT was 0.70 (range: 0.45-1.20) mm in patients with SLE and 0.40 (0.25-0.60) mm in controls ( P < .001). Endocan value was 1.6 ± 0.9 ng/mL in controls and 2.2 ± 1.0 ng/mL in patients with SLE ( P = .014). Endocan levels were positively correlated with cIMT ( r = .469, P < .001), body mass index ( r = .373, P = .013), and ESR ( r = .393, P = .008). Endocan level may be associated with subclinical atherosclerosis in SLE. Consequently, endocan levels may be a promising clinical tool for patients with SLE as a guide for preventive strategy.