Long-Term Mortality Rates in Acute De Novo Versus Acute-on-Chronic Heart Failure: From the Heart Function Assessment Registry Trial in Saudi Arabia. (October 2015)

• Record Type: Journal Article
• Authors: AlHabib, Khalid F.; Kashour, Tarek; Elasfar, Abdelfatah A.; Alfaleh, Hussam; Hersi, Ahmad; Alshamiri, Mostafa; Alshaer, Fayez; Mimish, Layth; Almasood, Ali; AlHabeeb, Waleed; AlGhamdi, Saleh; Ghabashi, Abdullah; Asfina, KaziNur; Altaradi, Hani; Alnobani, Omar; Alkamel, Nour; Thalib, Lukman
• Is Part Of: Angiology. Volume 66:Number 9(2015)
• Page Start: 837
• Page End: 844
• Publication Date: 2015-10
• Subjects: acute heart failure -- Saudi Arabia -- middle east -- HEARTS -- registry; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319714563138
• Languages: English
• ISSNs: 0003-3197

Abstract

Aim: The heart function assessment registry trial in Saudi Arabia (HEARTS) is a national multicenter project that compared de novo versus acute-on-chronic heart failure (ACHF). Methods and Results: This is a prospective registry in 18 hospitals in Saudi Arabia between October 2009 and December 2010. The study enrolled 2610 patients: 940 (36%) de novo and 1670 (64%) ACHF. Patients with ACHF were significantly older (62.2 vs 60 years), less likely to be males (64% vs 69%) or smokers (31.6% vs 36.7%), and more likely to have history of diabetes mellitus (65.7% vs 61.3%), hypertension (74% vs 65%), and severe left ventricular dysfunction (52% vs 40%). The ACHF group had a higher adjusted 3-year mortality rate (hazard ratio, 1.6; 95% confidence interval [CI] 1.3-2.0; P < .001). Conclusion: Patients with ACHF had significantly higher long-term mortality rates than those with de novo acute heart failure (HF). Multidisciplinary HF disease management programs are highly needed for such high-risk populations.