Modulation of 14C‐labeled glucose metabolism by zinc during aluminium induced neurodegeneration. Issue 9 (22nd April 2015)

• Record Type: Journal Article
• Authors: Singla, Neha; Dhawan, D.K.
• Is Part Of: Journal of neuroscience research. Volume 93:Issue 9(2015)
• Page Start: 1434
• Page End: 1441
• Publication Date: 2015-04-22
• Subjects: aluminium -- zinc -- 14C‐labeled glucose -- amino acids -- cerebrum -- cerebellum -- histology -- neurodegeneration; Neurobiology -- Periodicals; 612
• DOI: 10.1002/jnr.23596
• Languages: English
• ISSNs: 0360-4012

Abstract

Abstract : Aluminium (Al) is one of the most prominent metals in the environment and is responsible for causing several neurological disorders, including Alzheimer's disease. On the other hand, zinc (Zn) is an essential micronutrient that is involved in regulating brain development and function. The present study investigates the protective potential of Zn in the uptake of 14 C‐labeled amino acids and glucose and their turnover in rat brain slices during Al intoxication. Male Sprague Dawley rats (140–160 g) were divided into four different groups: normal control, Al treated (100 mg/kg body weight/day via oral gavage), Zn treated (227 mg/liter in drinking water), and Al + Zn treated. Radiorespirometric assay revealed an increase in glucose turnover after Al exposure that was attenuated after Zn treatment. Furthermore, the uptake of 14 C‐labeled glucose was increased after Al treatment but was appreciably decreased upon Zn supplementation. In addition, the uptakes of 14 C‐lysine, 14 C‐leucine, and 14 C‐aspartic acid were also found to be elevated following Al exposure but were decreased after Zn treatment. Al treatment also caused alterations in the neurohistoarchitecture of the brain, which were improved after Zn coadministration. Therefore, the present study suggests that Zn provides protection against Al‐induced neurotoxicity by regulating glucose and amino acid uptake in rats, indicating that Zn could be a potential candidate for the treatment of various neurodegenerative disorders. © 2015 Wiley Periodicals, Inc.