Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon. Issue 2 (3rd January 2018)

• Record Type: Journal Article
• Authors: Pinna, Raquel A.; dos Santos, Adriana C.; Perce‐da‐Silva, Daiana S.; da Silva, Luciene A.; da Silva, Rodrigo N. Rodrigues; Alves, Marcelo R.; Santos, Fátima; de Oliveira Ferreira, Joseli; Lima‐Junior, Josué C.; Villa‐Verde, Déa M.; De Luca, Paula M.; Carvalho‐Pinto, Carla E.; Banic, Dalma M.
• Is Part Of: Immunity, inflammation and disease. Volume 6:Issue 2(2018)
• Page Start: 207
• Page End: 220
• Publication Date: 2018-01-03
• Subjects: APRIL/BAFF -- malaria -- TACI; Immunology -- Periodicals; Immunity -- Periodicals; Inflammation -- Periodicals; 616.079
• DOI: 10.1002/iid3.208
• Languages: English
• ISSNs: 2050-4527

Abstract

Abstract: Introduction: A proliferation‐inducing ligand (APRIL) and B cell activation factor (BAFF) are known to play a significant role in the pathogenesis of several diseases, including BAFF in malaria. The aim of this study was to investigate whether APRIL and BAFF plasma concentrations could be part of inflammatory responses associated with P. vivax and P. falciparum malaria in patients from the Brazilian Amazon. Methods: Blood samples were obtained from P. vivax and P. falciparum malaria patients ( n = 52) resident in Porto Velho before and 15 days after the beginning of treatment and from uninfected individuals ( n = 12). We investigated APRIL and BAFF circulating levels and their association with parasitaemia, WBC counts, and cytokine/chemokine plasma levels. The expression levels of transmembrane activator and calcium‐modulating cyclophilin ligand interactor (TACI) on PBMC from a subset of 5 P. vivax ‐infected patients were analyzed by flow cytometry. Results: APRIL plasma levels were transiently increased during acute P. vivax and P. falciparum infections whereas BAFF levels were only increased during acute P. falciparum malaria. Although P. vivax and P. falciparum malaria patients have similar cytokine profiles during infection, in P. vivax acute phase malaria, APRIL but not BAFF levels correlated positively with IL‐1, IL‐2, IL‐4, IL‐6, and IL‐13 levels. We did not find any association between P. vivax parasitaemia and APRIL levels, while an inverse correlation was found between P. falciparum parasitaemia and APRIL levels. The percentage of TACI positive CD4+ and CD8+ T cells were increased in the acute phase P. vivax malaria. Conclusion: These findings suggest that the APRIL and BAFF inductions reflect different host strategies for controlling infection with each malaria species. Abstract : APRIL and BAFF levels in P. vivax and P. falciparum malaria.