Dictating genomic destiny: Epigenetic regulation of pancreatic neuroendocrine tumours. (5th July 2018)

• Record Type: Journal Article
• Authors: Gundara, Justin S.; Jamal, Karim; Kurzawinski, Tom
• Is Part Of: Molecular and cellular endocrinology. Volume 469(2018)
• Page Start: 85
• Page End: 91
• Publication Date: 2018-07-05
• Subjects: Epigenetic -- PNET -- Neuroendocrine tumour -- Methylation -- miRNA; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2017.03.032
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Pancreatic neuroendocrine tumours are a diverse group of neoplasms with an increasingly well-defined genomic basis. Despite this, much of what drives this disease is still unknown and epigenetic influences represent the next tier of gene, and hence disease modifiers that are of unquestionable importance. Moreover, they are of arguably more significance than the genes themselves given their malleable nature and potential to be exploited for not only diagnosis and prognosis, but also therapy. This review summarises what is known regarding the key epigenetic modifiers of disease through the domains of diagnosis, prognosis and treatment.