Epigenetics of pituitary tumors: Pathogenetic and therapeutic implications. (5th July 2018)

• Record Type: Journal Article
• Authors: Ezzat, Shereen; Cheng, Sonia; Asa, Sylvia L.
• Is Part Of: Molecular and cellular endocrinology. Volume 469(2018)
• Page Start: 70
• Page End: 76
• Publication Date: 2018-07-05
• Subjects: DNA methylation -- miRNA -- Histone modification -- Ikaros -- MAGE; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2017.07.011
• Languages: English
• ISSNs: 0303-7207

Abstract

Abstract: Genetic mutations involving oncogenes or tumor suppressor genes are relatively uncommon in human sporadic pituitary tumors. Instead, increasing evidence has highlighted frequent epigenetic alterations including DNA methylation, histone modifications, and enhanced miRNA expression. This review covers some of this evidence as it illuminates mechanisms of tumorigenesis and highlights therapeutic opportunities. Highlights: Pituitary tumors represent one of the most common forms of endocrine neoplasia. For decades, their pathogenesis remained elusive with limited insights from mutational genetic studies. In this review, we focus on the pituitary as a target of epigenetic changes with their pathogenetic and therapeutic implications.