Dose finding of 3′deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose. (August 2015)

• Record Type: Journal Article
• Authors: Dalla Rosa, Luciana; Da Silva, Aleksandro S.; Oliveira, Camila B.; Gressler, Lucas T.; Arnold, Caroline B.; Baldissera, Matheus D.; Sagrillo, Michele; Sangoi, Manuela; Moresco, Rafael; Mendes, Ricardo E.; Weiss, Paulo E.; Miletti, Luiz C.; Monteiro, Silvia G.
• Is Part Of: Microbial pathogenesis. Volume 85(2015)
• Page Start: 21
• Page End: 28
• Publication Date: 2015-08
• Subjects: Adenosine -- Trypanosomiasis -- Toxicity -- Cordycepin -- Pentostatin; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2015.05.005
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: The aim of this study was to evaluate the therapeutic efficacy and safety of using 3′deoxyadenosine (Cordycepin – adenosine analogue) combined with deoxycoformycin (Pentostatin – an adenosine deaminase inhibitor) in mice infected with Trypanosoma evansi . We show that the combination of Cordycepin (2.0 mg kg −1 ) and Pentostatin (0.2, 0.5, 1.0, 2.0 mg kg 1 ) is effective in the clearance of T. evansi, although at the higher concentrations of Pentostatin 2 mg kg −1 some toxicity was observed in the liver and kidney. Since the Cordycepin 2.0 mg kg −1 and Pentostatin 0.2 mg kg −1 combination was effective and had low toxicity, we recommend this as a therapeutic option for a T. evansi mouse model. Graphical abstract: Highlights: A new treatment for Trypanosoma evansi infection is proposed. The Cordycepin (2 mg/kg) and Pentostatin (0.2 mg/kg) combination was able to effectively eliminate T. evansi in infected mice. The higher concentrations of Cordycepin and Pentostatin combination showed some toxicity in the liver and kidney.