Susac's syndrome: Leptomeningeal enhancement on 3D FLAIR MRI. (June 2016)

• Record Type: Journal Article
• Authors: Engisch, Renate; Titelbaum, David S; Chilver-Stainer, Lara; Kellner-Weldon, Frauke
• Is Part Of: Multiple sclerosis. Volume 22:Number 7(2016)
• Page Start: 972
• Page End: 974
• Publication Date: 2016-06
• Subjects: Susac's syndrome -- contrast-enhanced FLAIR -- leptomeningeal pathology; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458516636836
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: Contrast-enhanced (ce) fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) has recently been shown to identify leptomeningeal pathology in multiple sclerosis. Objective: To demonstrate leptomeningeal enhancement on three-dimensional (3D) FLAIR in a case of Susac's syndrome. Methods: Leptomeningeal enhancement was correlated with clinical activity over 20 months and compared to retinal fluorescein angiography. Results: The size, number, and location of leptomeningeal enhancement varied over time and generally correlated with symptom severity. The appearance was remarkably similar to that of retinal vasculopathy. Conclusion: Ce 3D FLAIR may aid in diagnosis and understanding of pathophysiology in Susac's syndrome and may serve as a biomarker for disease activity.