Association between interferon-γ +874 T/A polymorphism and susceptibility to autoimmune diseases: a meta-analysis. (June 2016)

• Record Type: Journal Article
• Authors: Lee, Y H; Bae, S-C
• Is Part Of: Lupus. Volume 25:Number 7(2016)
• Page Start: 710
• Page End: 718
• Publication Date: 2016-06
• Subjects: Autoimmune diseases -- IFN -- polymorphism -- meta-analysis; Systemic lupus erythematosus -- Periodicals; 616.772005
• DOI: 10.1177/0961203315624557
• Languages: English
• ISSNs: 0961-2033

Abstract

Objective: The aim of this study was to explore whether the interferon ( IFN)-γ +874 T/A polymorphism plays a role in modifying the risk of autoimmune diseases. Methods: A meta-analysis was conducted on the association between the IFN-γ +874 T/A polymorphism and autoimmune diseases. Results: Eighteen studies with a total of 2952 patients and 3832 controls were included in the meta-analysis. The meta-analysis revealed no association between autoimmune diseases and the IFN-γ +874 T allele in all study subjects (odds ratio (OR)=1.023, 95% confidence interval (CI) = 0.894–1.171, p = 0.738), but stratification by ethnicity indicated an association between the IFN-γ +874 T allele and autoimmune diseases in Latin American subjects (OR = 0.780, 95% CI = 0.629–0.953, p = 0.015). Meta-analysis also revealed an association between autoimmune diseases and the IFN-γ +874 T/A polymorphism in Caucasian and Middle Eastern subjects under a dominant inheritance model (OR = 0.686, 95% CI = 0.489–0.964, p = 0.003; OR = 1.414, 95% CI = 1.102–1.813, p = 0.006). Meta-analysis by autoimmune disease type indicated an association between ITP and the IFN-γ +874 T allele (OR = 1.753, 95% CI = 1.228–2.503, p = 0.002), but not for vasculitis, vitiligo, and auto-immune thyroid disease. Meta-analysis also showed a significant association between the IFN-γ +874 T/A polymorphism and systemic lupus erythematosus (SLE) under the dominant model (OR = 1.668, 95% CI = 1.114–2.497, p = 0.013). Conclusions: This meta-analysis indicates that the IFN-γ +874 T/A polymorphism may play a significant role in modifying the risk of autoimmune diseases in Caucasian, Latin American, and Middle Eastern subjects, and in particular shows that the IFN-γ +874 T/A polymorphism is associated with increased genetic susceptibility to idiopathic thrombocytopenic purpura and SLE.