Current policy for allocation of donor livers in the Netherlands advantages primary sclerosing cholangitis patients on the liver transplantation waiting list—a retrospective study. (5th December 2017)

• Record Type: Journal Article
• Authors: Goet, Jorn C.; Hansen, Bettina E.; Tieleman, Madelon; van Hoek, Bart; van den Berg, Aad P.; Polak, Wojciech G.; Dubbeld, Jeroen; Porte, Robert J.; Konijn‐Janssen, Cynthia; de Man, Robert A.; Metselaar, Herold J.; de Vries, Annemarie C.
• Is Part Of: Transplant international. Volume 31:Number 6(2018)
• Page Start: 590
• Page End: 599
• Publication Date: 2017-12-05
• Subjects: Primary sclerosing cholangitis -- exception points -- liver transplantation -- waiting list mortality; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.13097
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: Studies from the USA and Nordic countries indicate primary sclerosing cholangitis (PSC) patients have low mortality on the liver transplantation (LTx) waiting list. However, this may vary among geographical areas. Therefore, we compared waiting list mortality and post‐transplant survival between laboratory model for end‐stage liver disease (LM) and MELD exception (ME)‐prioritized PSC and non‐PSC candidates in a nationwide study in the Netherlands. A retrospective analysis of patients waitlisted from 2006 to 2013 was conducted. A total of 852 candidates (146 PSC) were waitlisted of whom 609 (71.5%) underwent LTx and 159 (18.7%) died before transplantation. None of the ME PSC patients died, and they had a higher probability of LTx than LM PSC [HR obtained by considering ME as a time‐dependent covariate (HR ME 9.86; 95% CI 6.14–15.85)] and ME non‐PSC patients (HR ME 4.60; 95% CI 3.78–5.61). After liver transplantation, PSC patients alive at 3 years of follow‐up had a higher probability of relisting than non‐PSC patients (HR 7.94; 95% CI 1.98–31.85) but a significantly lower mortality (HR 0.51; 95% CI 0.27–0.95). In conclusion, current LTx prioritization advantages PSC patients on the LTx waiting list. Receiving ME points is strongly associated with timely LTx.