Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury. Issue 6 (19th March 2018)

• Record Type: Journal Article
• Authors: Rodriguez, Anne-Marie; Nakhle, Jean; Griessinger, Emmanuel; Vignais, Marie-Luce
• Is Part Of: Cell cycle. Volume 17:Issue 6(2018)
• Page Start: 712
• Page End: 721
• Publication Date: 2018-03-19
• Subjects: Stem cells -- mitochondria -- cell-cell interactions; Cell cycle -- Periodicals; 571.84377
• DOI: 10.1080/15384101.2018.1445906
• Languages: English
• ISSNs: 1538-4101

Abstract

ABSTRACT: Mitochondria are crucial organelles that not only regulate the energy metabolism, but also the survival and fate of eukaryotic cells. Mitochondria were recently discovered to be able to translocate from one cell to the other. This phenomenon was observed in vitro and in vivo, both in physiological and pathophysiological conditions including tissue injury and cancer. Mitochondria trafficking was found to exert prominent biological functions. In particular, several studies pointed out that this process governs some of the therapeutic effects of mesenchymal stem cells (MSCs). In this review, we give an overview of the current knowledge on MSC-dependent intercellular mitochondria trafficking and further discuss the recent findings on the intercellular mitochondria transfer between differentiated and mesenchymal stem cells, their biological significance and the mechanisms underlying this process.