Type I interferon licenses enhanced innate recognition and transcriptional responses to Franciscella tularensis live vaccine strain. Issue 5 (July 2016)

• Record Type: Journal Article
• Authors: Richard, Katharina; Vogel, Stefanie N; Perkins, Darren J
• Is Part Of: Innate immunity. Volume 22:Issue 5(2016:Jul.)
• Page Start: 363
• Page End: 372
• Publication Date: 2016-07
• Subjects: Francisella tularensis LVS -- IFN-β -- macrophage -- TLR2 -- type I interferon; Natural immunity -- Periodicals; Endotoxins -- Periodicals; 616.07905
• DOI: 10.1177/1753425916650027
• Languages: English
• ISSNs: 1753-4259

Abstract

The innate inflammatory response to Francisella tularensis ( Ft ) in macrophages is significantly governed by the expression of type I interferon (IFN). Previously, the proteolytic processing and maturation of pro-IL-1β protein was shown to depend upon type I IFN expression. We show in this report that paracrine type I IFN can profoundly enhance innate recognition and TLR-dependent transcriptional responses to Ft infection upstream of its role in inflammasome regulation in both primary human monocyte-derived macrophages and primary murine peritoneal macrophages but not murine bone marrow-derived macrophages. This type I IFN-enhanced response is synergistic with TLR2 transcriptional responses, partially TLR2-independent, but strictly MyD88-dependent.