Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy. Issue 17 (5th October 2017)

• Record Type: Journal Article
• Authors: Yang, Caixia; Lin, Gan; Zhu, Congqing; Pang, Xin; Zhang, Yang; Wang, Xiaoyong; Li, Xianglin; Wang, Bin; Xia, Haiping; Liu, Gang
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 17(2018)
• Page Start: 2528
• Page End: 2535
• Publication Date: 2017-10-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb02145c
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : In this study, metalla-aromatic agents and a cluster of superparamagnetic iron oxide nanoparticles were loaded inside a micellar carrier and used for MRI/PA imaging-guided PTT/PDT synergistic cancer therapy. Abstract : In this study, metalla-aromatic agents (MA) and a cluster of superparamagnetic iron oxide nanoparticles (SPIOs) were loaded inside a micellar carrier (Alkyl-PEI2k-PEG), resulting in MA/SPIOs@Alkyl-PEI2k-PEG nanoparticles (MASAs). The prepared MASAs with a photothermal transduction efficiency of 26.6% were also demonstrated as a potential photodynamic sensitizer to generate ROS effectively. Under the guidance of MRI/photoacoustic imaging, combined photothermal and photodynamic therapy achieved a synergistic anti-tumor effect, significantly improving the therapeutic efficacy of MASAs both in vitro and in vivo . This work shows that the developed MASAs are a potential theranostic agent for dual-modal imaging-guided cancer phototherapy.