Bis coumarinyl bis triazolothiadiazinyl ethane derivatives: Synthesis, antiviral activity evaluation, and molecular docking studies. Issue 12 (18th June 2018)

• Record Type: Journal Article
• Authors: Pavurala, Sreenu; Vaarla, Krishnaiah; Kesharwani, Rajeshkumar; Naesens, Lieve; Liekens, Sandra; Vedula, Rajeswar Rao
• Is Part Of: Synthetic communications. Volume 48:Issue 12(2018)
• Page Start: 1494
• Page End: 1503
• Publication Date: 2018-06-18
• Subjects: Antiviral activity -- coumarins -- influenza virus -- molecular docking -- thiocarbohydrazide; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2018.1455871
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: A series of novel 3, 3′-(3, 3′-(dihydroxy/hydroxyethane-1, 2-diyl)bis(7 H -[1, 2, 4]triazolo[3, 4- b ][1, 3, 4]thiadiazine-6, 3-diyl))bis(2 H -chromen-2-ones) were prepared by the condensation of thiocarbohydrazide with tartaric acid or malic acid followed by various 3-(2-bromoacetyl)-2 H -chromen-2-ones in two steps with good yields. All the synthesized compounds were characterized by analytical and spectral (IR, 1 H NMR, 13 C NMR, and mass) data. These synthesized bis(triazolothiadiazinyl coumarin) compounds were evaluated for broad spectrum of antiviral activity. Among all the tested compounds, compound5f exhibited antiviral activity against H1N1 virus. The molecular docking studies of these compounds against H1N1 neuraminidase enzyme were performed. The binding affinity and binding values were compared with standard drugs. GRAPHICAL ABSTRACT: