Intracellular pH-induced fluorescence used to track nanoparticles in cells. Issue 27 (5th June 2015)

• Record Type: Journal Article
• Authors: Cheng, F. R.; Chen, Y.; Su, T.; Cao, H.; Li, S.; Cao, J.; He, B.; Gu, Z. W.; Luo, X. L.
• Is Part Of: Journal of materials chemistry. Volume 3:Issue 27(2015)
• Page Start: 5411
• Page End: 5414
• Publication Date: 2015-06-05
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c5tb00756a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : pH-induced fluorescence conversion of spiropyran in nanoparticles was used as a probe for intracellular tracing and pH-sensitive drug release. Abstract : A nanoparticle with pH-induced fluorescence was reported for intracellular tracking. The fluorescence was evoked by the isomerization of the ring-closed form spiropyran (SP) to the ring-open form merocyanine (MC) in the weak acidic environment of cells. The SP–MC switch accelerated the dissociation of nanoparticles to trigger the release of trapped paclitaxel.