A model β-sheet interaction and thermodynamic analysis of β-strand mimetics. Issue 27 (19th June 2015)

• Record Type: Journal Article
• Authors: Robinson, Colin W.; Rye, Carl S.; Chessum, Nicola E. A.; Jones, Keith
• Is Part Of: Organic & biomolecular chemistry. Volume 13:Issue 27(2015)
• Page Start: 7402
• Page End: 7407
• Publication Date: 2015-06-19
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c5ob00886g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Two novel β-strand mimetics are synthesized and their binding to a model peptide is studied in detail by 1 H NMR. Abstract : β-Sheet mediated protein–protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using 1 H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.