Continuous nanoparticles production through a combination of a micro electro mechanical system and an electromagnetic resonator cavity. (18th August 2018)

• Record Type: Journal Article
• Authors: Yousefi-Seyf, Jaber; Zarghami, Reza; Haririan, Ismaeil
• Is Part Of: Particulate science and technology. Volume 36:Number 6(2018)
• Page Start: 666
• Page End: 671
• Publication Date: 2018-08-18
• Subjects: Curcumin -- loratadine -- nanoparticles -- narrow particle size distribution -- piezoelectric -- surface acoustic wave; Particles -- Periodicals; 620.43
• DOI: 10.1080/02726351.2017.1287796
• Languages: English
• ISSNs: 0272-6351

Abstract

ABSTRACT: In the present work, a reliable, rapid, and controllable method is developed for the continuous generation of pharmaceutical curcumin and loratadine nanoparticles (NPs). Micro droplets of curcumin and loratadine were generated by atomization of their corresponding solutions by a combination of a micro electro mechanical system and an electromagnetic resonator cavity. After evaporation of the solvent of micro droplets by electromagnetic waves, the NPs were collected by a polytetrafluoroethylene (PTFE) filter. NPs were characterized by scanning electron microscopy. Results showed that this method can be an effective way to produce amorphous NPs with narrow particle size distribution, where particle size can be easily controlled by solution concentration. Particles size varies from 152 to 446 nm and from 116 to 719 nm for loratadine and curcumin, respectively.