Vascular endothelial growth factor (−460 C/T, +405 G/C, and +936 C/T) polymorphisms and endometriosis risk in Tunisian population. (14th May 2015)

• Record Type: Journal Article
• Authors: Henidi, Belkis; Kaabachi, Wajih; Naouali, Abir; Kaabachi, Safa; Zhioua, Amel; Haj Sassi, Faycal; Hamzaoui, Kamel
• Is Part Of: Systems biology in reproductive medicine. Volume 61:Number 4(2015:Aug.)
• Page Start: 238
• Page End: 244
• Publication Date: 2015-05-14
• Subjects: Endometriosis -- gene -- polymorphism -- vascular endothelial growth factor -- VEGF; Systems biology -- Periodicals; Andrology -- Periodicals; Generative organs, Male -- Diseases -- Periodicals; Biological systems -- Periodicals; Reproductive health -- Periodicals; Human reproduction -- Periodicals; 612.61
• DOI: 10.3109/19396368.2015.1041622
• Languages: English
• ISSNs: 1939-6368

Abstract

Abstract: The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (−460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian population. This study includes 105 women with endometriosis and 150 women with no laparoscopic evidence of disease. Genotyping of the VEGF −460 C/T, +405 G/C, and +936 C/T polymorphisms were performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes ( P = 0.006) and allele ( P = 0.0009) frequencies of the +936 C/T polymorphism was significantly different between patients and controls. Patients with stages III-IV endometriosis showed a higher VEGF + 936T allele frequency than controls ( P = 0.0001). However, the distribution of genotypes and allele frequencies of the VEGF −460 C/T and +405 G/C polymorphisms did not differ significantly between endometriosis patients and controls. These findings suggest that the VEGF +936 C/T polymorphism may be a risk factor for endometriosis development and the VEGF +936 T allele is associated with an increased risk of stages III-IV endometriosis in the Tunisian population.