A convergent formal [4 + 2] cycloaddition of 1, 6-diynes and benzyl azides: construction of spiro-polyheterocycles. Issue 17 (17th April 2018)

• Record Type: Journal Article
• Authors: Bao, Ming; Lu, Wei; Su, Han; Qiu, Lihua; Xu, Xinfang
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 17(2018)
• Page Start: 3258
• Page End: 3265
• Publication Date: 2018-04-17
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob00735g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A convergent one-pot formal [4 + 2] cycloaddition reaction for the construction of structurally appealing spiro-tetrahydroquinolines has been developed. Abstract : A convergent formal [4 + 2] cycloaddition reaction for the construction of structurally appealing spiro-tetrahydroquinolines has been developed, in which, a one-pot reaction is established for the in situ generation of two reagents, a cyclic alkyne and an N -aryliminium ion, from the corresponding precursors in the presence of an Au-catalyst and Brønsted acid, respectively.