An efficient synergistic cancer therapy by integrating cell cycle inhibitor and photosensitizer into polydopamine nanoparticles. Issue 17 (6th March 2018)

• Record Type: Journal Article
• Authors: Yan, Shufeng; Song, Xiaorong; Liu, Yan; Dai, Tao; Huang, Mingdong; Chen, Xueyuan; Chen, Zhuo
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 17(2018)
• Page Start: 2620
• Page End: 2629
• Publication Date: 2018-03-06
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c8tb00076j
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : A novel polydopamine (PDA) based nanocomposite loaded with cell cycle inhibitor (NOC) and photosensitizer (ZnPc12 + ) was developed for efficient synergistic cancer therapy. Abstract : Multifunctional nanomedicines are highly demanded in the development of new cancer theranostic approaches to achieve more effective and safer treatment. Herein, we designed a polydopamine (PDA) nanoparticle by loading with cell cycle inhibitor nocodazole (NOC) and photosensitizer ZnPc(TAP)4 12+ (ZnPc12 + ) for simultaneous tumor imaging and efficient synergistic therapy. It was found that the loaded NOC can facilitate enhanced nuclear uptake of ZnPc12 + in MCF-7 cells, resulting in PDA-NOC–ZnPc12 + nanoparticles not only inhibiting cell proliferation and inducing cell cycle G2 /M arrest, but also improving photodynamic therapy (PDT) efficacy. Compared with the respective single anticancer action, PDA-NOC–ZnPc12 + nanoparticles exhibited better anticancer efficacy in tumor-bearing mice, demonstrating the synergistic effect of combination therapy with a cell cycle inhibitor and photosensitizer. Particularly, PDA-NOC–ZnPc12 + resulted in a high accumulation of ZnPc12 + in tumors but low retention in livers, without rendering distinct toxicity to the treated animals. Such PDA-based nanocarriers functionalized with dual-drug loading and bioimaging may have great potential for diagnosis and combination therapy of cancer.