Diastereo- and enantioselective construction of chiral cyclopenta[b]indole framework via a catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols. Issue 9 (12th March 2018) - Wu, Jia-Le
Abstract : The title reaction has been established in the presence of chiral phosphoric acids, which constructed chiral cyclopenta[ b ]indole frameworks in high stereoselectivities. Abstract : A catalytic asymmetric tandem cyclization of 2-indolymethanols with 2-naphthols has been established in the presence of chiral phosphoric acids, which constructed chiral cyclopenta[ b ]indole frameworks in generally good yields (up to 90%), high diastereoselectivities (up to >95 : 5 dr) and excellent enantioselectivities (up to 96% ee). This reaction not only provides an easy access to chiral cyclopenta[ b ]indole scaffolds, but also advances the chemistry of indolylmethanols, especially catalytic asymmetric transformations of indolylmethanols.