A mitochondria-selective near-infrared-emitting fluorescent dye for cellular imaging studies. Issue 11 (15th June 2018)

• Record Type: Journal Article
• Authors: Choi, Peter; Noguchi, Katsuya; Ishiyama, Munetaka; Denny, William A.; Jose, Jiney
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 28:Issue 11(2018)
• Page Start: 2013
• Page End: 2017
• Publication Date: 2018-06-15
• Subjects: Near infrared fluorescent dyes -- Mitochondria -- Amoxapine -- Cyanine dye -- Organelle selective fluorescent dyes; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2018.05.001
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: A near infrared emitting drug-dye conjugate with selective staining of mitochondria. The synthesis, photo-physical properties, cellular imaging studies reported. Mitochondrial membrane depolarization studies are also reported. Abstract: This communication details the synthesis, evaluation of photophysical properties, and cellular imaging studies of cyanine chromophore based fluorescent dye1 as a selective imaging agent for mitochondria.