Blood-brain barrier dysfunction and recovery after ischemic stroke. (April 2018)

• Record Type: Journal Article
• Authors: Jiang, Xiaoyan; Andjelkovic, Anuska V.; Zhu, Ling; Yang, Tuo; Bennett, Michael V.L.; Chen, Jun; Keep, Richard F.; Shi, Yejie
• Is Part Of: Progress in neurobiology. Volume 163/164(2018)
• Page Start: 144
• Page End: 171
• Publication Date: 2018-04
• Subjects: ABC ATP-binding cassette -- AJ adherens junction -- Ang angiopoietin -- ApoE apolipoprotein E -- AQP4 aquaporin 4 -- BBB blood-brain barrier -- cAMP cyclic AMP -- CSF cerebrospinal fluid -- EAAT excitatory amino acid transporter -- EC endothelial cell -- ECF extracellular fluid -- ECM extracellular matrix -- eNOS endothelial nitric oxide synthase -- ER estrogen receptors -- GDNF glial cell-derived neurotrophic factor -- GLUT1 glucose transporter isoform 1 -- GPER-1 G protein-coupled estrogen receptor 1 -- HFD high fat diet -- HIF hypoxia-inducible factor -- HMGB1 high-mobility group box1 -- ICAM intercellular adhesion molecule -- IL interleukin -- iPSC induced pluripotent stem cell -- JAM junctional adhesion molecule -- LAT L-type amino acid transporter -- LDL low-density lipoprotein -- L-NAME Nω-Nitro-l-arginine methyl ester -- LPS lipopolysaccharide -- MAPK mitogen-activated protein kinase -- MCAO middle cerebral artery occlusion MCAO -- MCP1 monocyte chemoattractant protein 1 -- MIF macrophage migration inhibitory factor -- MMP metalloproteinase -- MRI magnetic resonance imaging -- NO nitric oxide -- NOS nitric oxide synthase -- NVU neurovascular unit -- OGD oxygen glucose deprivation -- PAI photoacoustic imaging -- PDGFR platelet-derived growth factor receptor -- PECAM-1 platelet endothelial cell adhesion molecule 1 -- PET positron emission tomography -- P-gp P-glycoprotein -- PI3K phosphatidylinositide 3-kinase -- PKC protein kinase C -- ROCK Rho-associated protein kinase -- ROS reactive oxygen species -- shh sonic hedgehog -- SHR spontaneously hypertensive rat -- SHRSP stroke-prone spontaneously hypertensive rat -- SOD superoxide dismutase -- TEER transendothelial electrical resistance -- TGFβ transforming growth factor beta -- TJ tight junction -- TNF tumor necrosis factor -- tPA tissue plasminogen activator -- Treg regulatory T-cells -- VCAM vascular cell adhesion protein -- VEGF vascular endothelial growth factor -- WKY Wistar Kyoto -- ZO zonula occludens; Inflammation -- Neurovascular unit -- Repair -- Stroke comorbidities -- Tight junction; Neurobiology -- Periodicals; Neurology -- Periodicals; Neurology -- Periodicals; Neurobiologie -- Périodiques; 612.8
• DOI: 10.1016/j.pneurobio.2017.10.001
• Languages: English
• ISSNs: 0301-0082

Abstract

Highlights: Mechanisms of blood-brain barrier dysfunction after ischemic stroke. Regulation of blood-brain barrier integrity by cells in the neurovascular unit. Stroke comorbidities and blood-brain barrier dysfunction. Blood-brain barrier recovery and repair after ischemic stroke. Advanced tools to study the blood-brain barrier. Abstract: The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes and cells at the blood-brain interface and maintaining the homeostatic microenvironment of the CNS. Under pathological conditions, such as ischemic stroke, the BBB can be disrupted, followed by the extravasation of blood components into the brain and compromise of normal neuronal function. This article reviews recent advances in our knowledge of the mechanisms underlying BBB dysfunction and recovery after ischemic stroke. CNS cells in the neurovascular unit, as well as blood-borne peripheral cells constantly modulate the BBB and influence its breakdown and repair after ischemic stroke. The involvement of stroke risk factors and comorbid conditions further complicate the pathogenesis of neurovascular injury by predisposing the BBB to anatomical and functional changes that can exacerbate BBB dysfunction. Emphasis is also given to the process of long-term structural and functional restoration of the BBB after ischemic injury. With the development of novel research tools, future research on the BBB is likely to reveal promising potential therapeutic targets for protecting the BBB and improving patient outcome after ischemic stroke.