Recent advances in near-infrared light-responsive nanocarriers for cancer therapy. Issue 5 (May 2018)

• Record Type: Journal Article
• Authors: Saneja, Ankit; Kumar, Robin; Arora, Divya; Kumar, Sandeep; Panda, Amulya K.; Jaglan, Sundeep
• Is Part Of: Drug discovery today. Volume 23:Issue 5(2018)
• Page Start: 1115
• Page End: 1125
• Publication Date: 2018-05
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2018.02.005
• Languages: English
• ISSNs: 1359-6446

Abstract

Highlights: NIR light allows deeper tissue penetration and minimum damage to healthy tissues. The uses of NIR responsive nanomaterials in cancer therapy are highlighted. Recent trends of using multi-stimuli responsive nanocarriers have been discussed. The challenges related to NIR responsive nanomaterials are described. Abstract : In recent years, research has focused on the development of smart nanocarriers that can respond to specific stimuli. Among the various stimuli-responsive platforms for cancer therapy, near-infrared (NIR) light (700–1000 nm)-responsive nanocarriers have gained considerable interest because of their deeper tissue penetration capacity, precisely controlled drug release, and minimal damage towards normal tissues. In this review, we outline various therapeutic applications of NIR-responsive nanocarriers in drug delivery, photothermal therapy (PTT), photodynamic therapy (PDT), and bioimaging. We also highlight recent trends towards NIR-responsive combinatorial therapy and multistimuli-responsive nanocarriers for improving therapeutic outcomes.